Since there are usually multiple variables that merit subgroup comparisons, the risk of false positive findings due to multiple comparisons compounds the risk of false negative findings due to low statistical power.
If an identifier was ambiguous in one or both of the databases (i.e., the identifier was associated with multiple compounds within the database(s)), the identifier was also considered ambiguous across databases.
Many people are also simultaneously investors in many funds at multiple stages, compounding the sensitivity.
Therefore, to reflect the roles of multiple compounds for the therapeutic functions, dracorhodin, (2S -5-methoxyflavan-7-ol and (2S -5-methoxyflavan-7-olavan-7-ol should be chosen as analytical markers for a more comprehensive quality evaluation of DB medicine.
However, there is greater evidence for the presence of multiple compounds in the form of findings showing a greater antimicrobial effect of oregano oil than of purified carvacrol [ 36].
The only way to address that is with a systematic approach to actively predict what compounds are likely to be present, and couple that with testing that is far more robust and can detect multiple compounds at the same time.
Invariably, HN5 and HT29 xenografts showed greater growth inhibition, while A375P and PC3 xenografts demonstrated much lower growth inhibition using multiple compounds at the same dose and schedule.
The method is specific for compounds that will undergo LC-ECA oxidation or reduction, and includes multiple compounds from the tyrosine, tryptophan, sulfur amino acid and purine pathways, as well as markers of oxidative stress and protection (see Additional file 1: Table S1).
It is most probable that the cytotoxic effects of the extract of Mangifera indica L. on breast cancer cells as shown in this study are due to more than one bioactive compound in view of the multiple compounds detected in the extract and since a crude extract was used.
Transitions are diverse and complex, may involve uncertainty, can be sequential or simultaneous, and often occur in multiples that compound the effect of transitions [ 5, 36].
