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Future work might also include applicability domain calculation, jittering of multiple compounds that are mapped to the same 3D position, and the implementation of an additional java-based dimensionality reduction technique.
The identification of multiple compounds that affect sirtuin activity and improve PD pathogenesis is encouraging.
In conclusion, HTS assays of CSCs provide opportunities to identify multiple compounds that could represent new revolutionary therapies.
It should also be noted that the LOPAC library contains multiple compounds that target the same protein or related proteins, another factor likely to contribute to a high hit rate.
The Food Quality Protection Act (1996) requires the U.S. Environmental Protection Agency to evaluate both children's aggregate exposure (multiple exposure pathways for a single pesticide) and cumulative risk (potential health effects from exposure to multiple compounds that have a common mechanism of toxicity).
If workers are exposed to multiple compounds that act by the same mechanism, effects may be additive or synergistic, even though no single exposure occurs above occupational exposure limits (NIOSH 2005).
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In addition, because the mechanisms of cartilage degradation in OA are multifactorial and some nutritional compounds (such as plant extracts) usually contain multiple active compounds that target multiple pathways, nutrition could provide an alternative to pharmacological interventions whose often monomodal mode of action may explain their partial lack of clinical efficacy in OA.
This suggests that the C. longa extract may contain multiple bioactive compounds that target S. aureus.
Neem contains multiple active compounds that work simultaneously via different mechanisms (10– 10).
Azadirachta indica (common name: neem) contains multiple active compounds that have potent anti-inflammatory and anticancer properties.
In fact, it has been argued that plants may be sources of multiple bioactive compounds that could provide more benefit than single pharmacological agents against chronic diseases, and this may well be beneficical in managing breast cancer.
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