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Invariably, HN5 and HT29 xenografts showed greater growth inhibition, while A375P and PC3 xenografts demonstrated much lower growth inhibition using multiple compounds at the same dose and schedule.
Furthermore, few data are available on the potential human-health effects resulting from long-term exposure to multiple compounds at low concentrations.
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The cermet sensor arrays used in this analysis are rugged, low cost, reusable, and show promise for multiple compound detection at parts-per-million (ppm) levels.
This model shows that simultaneous exposure to multiple compounds will produce an effect that is consistent with additivity at the VGSC molecular target.
In all cases where we apply tests to multiple compounds in parallel, we use the Benjamini-Hochberg False Discovery Rate (FDR) [32] at a value of q = 1/25.
What would happen if we introgressed that and got multiple compounds in a strawberry?
Unfortunately, establishing synergistic compound combinations at greater scale is typically hampered by the necessity to screen multiple compound concentrations of one compound against different concentrations of another compound.
The pirate won 19 months after an accident at Milan Turin which would have ended the career of many riders – he suffered multiple compound fractures to his left leg.
Using this Locus Derepression assay, we queried 283,122 compounds by quantitative high-throughput screening evaluating compounds at multiple concentrations.
Since these assays are endpoint assays, we performed the analysis at the 47-h time point since performing these assays over time would require another full screen of 308 compounds at multiple concentrations for each time point.
Ideally, false-call rates could be minimized by using 'statistical power' to establish appropriate sample sizes (Ellis, 2010; Grissom and Kim, 2011; Halsey et al., 2015) and by testing compounds at multiple concentrations, a strategy called 'quantitative HTS' (qHTS; [ Inglese et al., 2006]).
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