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There are three major ways that multiple compounds are applied to slices: by bath, via a U-tube device, or by pressure application using a "puffer" pipette.
Diversity-Oriented Synthesis (DOS), also known as combinatorial synthesis, is a process, by which multiple compounds are generated simultaneously, in a predictable fashion using techniques that involve parallel chemical transformations.
Higher-order activity cliff configurations involving multiple compounds are of particular interest for medicinal chemistry, given their high SAR information content.
Careful experimental work will be needed in order to demonstrate that multiple compounds are in fact produced and confer benefits in vivo [ 19].
Similar(56)
Multiple compounds were identified as potent HDAC inhibitors (HDACi), with IC50 values in the low nanomolar (nM) range against enzyme activity in HeLa cell extracts and sub-μM for their in vitro anti-proliferative effect on cell lines.
Based on this, a single-cell biorefinery concept, namely, a single-cell factory that coutilizes different components in biomass or waste material and coproduces value-added multiple compounds, is proposed and discussed.
Currently, the release of multiple compounds is mainly controlled by polymer degradation, molecular diffusion, or a combination of both.
In addition, the importance of mixture effects of low-dose exposure to multiple compounds is becoming evident from animal studies but remains to be studied in humans (Hass et al. 2007; Kortenkamp et al. 2007).
To date, multiple compounds have been tested in pre-clinical studies and phase ll clinical trials.
Multiple compounds have been identified that sensitize cancer cells to TRAIL-induced apoptosis.
In fact, therapies based on coordinated actions of multiple compounds have been used as early as the dawn of medicine.
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