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Finally, the map shows multiple complexes implicated in RNA and DNA transcription, DNA replication and structure maintenance.
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Lage, K. et al. A human phenome interactome network of protein complexes implicated in geneticdisorders.Nat.
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.
The SWI/SNF complex is not the only chromatin remodelling complex implicated in centromere function.
Canonical WNT signalling is central to numerous developmental processes and variants discovered within members of this pathway have been implicated in multiple complex diseases such as familial adenomatous polyposis coli, colorectal and hepatocellular cancers, type 2 diabetes and schizophrenia [ 10- 14].
Another reason for this debate stems from the multiple and complex processes implicated in achieving UHC.
Indeed, Nef interacts with multiple proteins implicated in membrane trafficking in order to downregulate cell surface levels of major histocompatibility complex class I (MHC-I), resulting in a decreased ability of infected CD4+ T-cells to be detected and killed by CD8+ cytotoxic T lymphocytes (CTLs 5.
He's living multiple complex situations.
Immune complexes are implicated in the pathogenesis by the observation that multiple anti-GPI antibodies with non-overlapping epitope specificities – as would be required to form an antigen antibody lattice – are required for the initiation of arthritis [ 70].
For each complex food outbreak, we partitioned the associated illnesses to the multiple implicated commodities in proportion to the relative numbers of illnesses in all simple food outbreaks that implicated those specific commodities; we then added the results from all outbreaks to obtain commodity illness percentages.
Second, association formally implicates regions, not genes, and in some cases, a single 'true' signal may, by LD, result in multiple genes being implicated.
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