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PRL1 (Pleiotropic Regulatory Locus 1) encodes a WD40 protein that is a component of a spliceosome complex, and prl1 mutations have multiple complex phenotypes that include sugar hypersensitivity [ 10].
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Human diseases are complex phenotypes involving multiple organ systems, thus the role of PAR2 still needs to be pursued in many experimental models.
Comparative QTL mapping and meta-analysis, however, provides another means to unify, and thereby simplify molecular analysis of complex phenotypes across multiple data sets.
Examples provided in this review illustrate how multiple papers have slowly built complex phenotypes over time, aspects of which were either initially missed or not reported.
Joint modeling of multiple responses to accurately capture complex phenotypes has been shown to increase power of discovery in genome-wide association studies [ 111].
We suggest that inherent robustness of vertebrate developmental and morphogenetic processes, with multiple pathways converging to generate complex phenotypes, can mask distinctive molecular phenotypes associated with different WGD paralogues.
Quantitative genetic methods enable more effective selection on single or multiple complex traits than selection on phenotypes because of the estimation of additive genetic variance in the population (the chief cause of resemblance of relatives and the only genetic component that can be estimated from observations on the population) and estimated breeding values of individuals.
This approach provides an alternative route for identifying transcription factor mutants with improved tolerance against various stresses, and will be an effective strategy for improving other similar complex phenotypes involved in multiple genes in the future.
However, tolerances are complex phenotypes determined by multiple genes [5].
All efforts to represent complex phenotypes will require multiple ontologies and post-composition, and they will thus experience the same general problems.
Similar to T2DM, diabetic complications are complex phenotypes determined by multiple pathways with a large genetic component.
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