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The multiple complementarity of the proto-adapters (by considering U-G pairs) increases the synonymy of the reactions.
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Notably, TCR antigen-binding sites are composed of multiple CDR (complementarity determining region) loops generated via recombination processes similar to those used in antibody generation.
These miRNA-containing complexes have been shown to bind to the 3' untranslated region of multiple mRNAs through complementarity between the resident miRNA strand and the target sequence and, based on the degree of homology, direct either translational inhibition or mRNA degradation [ 16].
We have shown that synthetic duplex RNAs with at least partial complementarity to multiple transcripts are capable of specific suppression of multiple target genes.
Thus, the redundancy and complementarity of multiple assays allow an integration of data across multiple assay technologies to boost confidence in the results.
The compound 7812 extends into this cavity and provides surface complementarity through multiple ring structures.
The Fixed-Randomized primers bind with full sequence complementarity at multiple sites where the fixed sequence (such as the splice signals) occurs within the genome, and multiplex amplify many regions bounded by the fixed sequences (e.g., exons).
Antisense gapmer oligonucleotides that exclusively demonstrate reverse complementarity to multiple cDNAs related to particular disorders.
The present study demonstrates proof of concept for the design of artificial short RNAs with at least partial complementarity to multiple unrelated transcripts, and which suppress the expression of the corresponding unrelated genes.
However, it has been well reported that small RNAs can be effective against single and multiple target mRNAs with incomplete complementarity [34], [35].
Some of the discovered miRNAs showed high sequence complementarity to the multiple regions in one mRNA, whereas others were designated as potentially targeting a few different molecules.
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