Additionally, complimenting the average activity analysis approach, described above, all ROIs of significance also demonstrated clusters of activity that survived familywise error rate correction for multiple comparisons within these small volumes (P<0.05; Table 1).
We then carried out a small volume correction (SVC) for multiple comparisons within a sphere of radius 5 mm, centered at co-ordinates representing maxima within this cluster.
These results survived SVC for multiple comparisons within a sphere of radius 5 mm centered at co-ordinates representing maxima within that cluster.
Finally, comparing the premonitory scans > baseline scans, in the nausea group > no-nausea group with an uncorrected threshold of p < 0.05, we again found activations in the dorsal rostral medulla and the PAG, which survived SVC for multiple comparisons within a sphere radius of 5 mm centered at co-ordinates representing maxima within that cluster (Figure 1 and Table 4).
ANOVA with Tukey's test was used for multiple comparisons within a group.
Multiple comparisons within each temporal group showed an indirect negative interaction between R. porosum and B. cinerea.
For the amygdala, which was our region of interest, we corrected for multiple comparisons within an anatomically defined region of interest [35] at p<0.05, FWE corrected.
We employed Bonferroni correction to take into account the 22×23 multiple comparisons within each sample (i.e. |z|> 4.756 for the null hypothesis to be rejected).
To account for multiple comparisons within the pathway (all 48 candidate gene regions in this analysis), we applied the false discovery rate (FDR) method of Benjamini and Hochberg [50] to the minP test separately for NHL and each subtype.
Two sample T tests were used within SPM5 to evaluate potential differences between genetic groups with a statistical threshold p<0.005, with further correction for multiple comparisons within ROIs in putamen obtained with the WFU_PickAtlas tool, p = 0.05.
Although there were statistically marginally significant differences observed with respect to week 16 cholesterol and non HDL cholesterol (p = 0.04 and p = 0.03, not corrected for multiple comparisons), within each arm there were no significant changes from baseline.
