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Using SPM99, the statistical significance was corrected for multiple comparisons based on the size of each cluster of contiguous voxels having t>3.17, corresponding to p=0.001 uncorrected (df=100).
To identify outliers, Mahalanobis distances for the matrix of slice-wise mean and standard deviation values (concatenated) × functional volumes (time) were computed, and any values with a significant χ2 value (corrected for multiple comparisons based on the more stringent of either FDR or Bonferroni methods) were considered outliers (less than 1% of images were outliers).
Similar to the univariate GLM analysis above, significant clusters were initially masked by a gray matter mask, and then determined using a height threshold of P<0.01 and an extent threshold of P<0.05 with family-wise error correction for multiple comparisons based on nonstationary suprathreshold cluster-size distributions63.
Q-values were calculated to control for multiple comparisons based on an FDR value of 10% [47].
Activation at the threshold of t>3 with a cluster size of 10 (approximately p<0.001 corrected for multiple comparisons based on AlphaSim software [64]) was arbitrarily chosen to generally determine group activation regions.
The significance level for this analysis was p<0.0026, corresponding to a significance of p<0.05 for the whole amygdala (corrected for multiple comparisons based on the number of analyzed resolution elements).
Similar(39)
Analysis of the cell headspace by TD-GC MS idenTD-GC MS1 common compounds that formed a data set for multidentifiedy comparisons based on TD-GC–MS quantitation (area-under-curve values) relative to media-only intra-experiment controls (Supplementary Tables S1 and S2).
All p-values are corrected for multiple non-independent comparisons based on the theory of smooth random fields (p = 0.05 FDR-corrected) [25].
Multiple pair wise comparisons based on the Mardia-Watson-Wheeler test were also used to test for inter-individual differences in stage 1 and final escape angle.
Type III sums of squares were evaluated and multiple comparisons were based on Tukey-Kramer adjusted P-values.
Moreover, since the Mann-Whitney U test is not designed to test for significance in multiple comparisons, results based on this two-sample test were verified by employing a parametric multiple-comparison method, Fisher's PLSD test (a nonparametric test for pairwise multiple comparisons was unavailable).
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