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Associations between index SNPs and CpGs, with only those meeting multiple comparison criteria.
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We then corrected the main effect of the time image for multiple comparisons using criteria from a Monte Carlo simulation (http://afni.nimh.nih.gov/afni/doc/manual/AlphaSim), which indicated that a cluster size of at least 17 contiguous voxels was required along with an individual voxel P value of 0.001 in order to achieve a corrected image-level significance of P < 0.05.
The gene set enrichment analysis was performed using WebGestalt [ 16], with the Entrez Gene set as a reference, using a hypergeometric test with Benjamini-Hochberg multiple comparison adjustment correction (significance criterion: adjusted p-value adjP < 0.05) and the maximum number of significant hits M = 40.
To assure a multiple comparisons corrected p<.05 criteria, significant regions were identified based on a per-voxel minimum z>2.32 and minimum cluster size of 37 voxels within the CCN mask (or 30 voxels within the EMO mask).
If normality criteria were met, one way ANOVA with post-hoc Fisher LSD test were run; if normality criteria were not met, Kruskal-Wallis multiple comparison were run.
Multiple comparison post-hoc tests using Tukey's honestly significant difference criterion were used to investigate potential differences between individual groups.
This criterion is considered as good procedure for multiple comparison correction in time series [ 17].
The performances of the different models for estimating the FDR and related criteria are first illustrated on the results of simulated multiple comparison tests.
These comparisons were also repeated with more restricted statistical criteria using the Benjamini-Hochberg multiple comparisons correction, with the criterion of FDR < 1 %.
No multiple comparison corrections were performed.
The coverage offered and the premium price can be the comparison criteria too.
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