Sentence examples for multiple common risk from inspiring English sources

The two conditions share multiple common risk factors that should be readily controlled for when assessing a possible association.

It is now thought that there are both multiple common risk alleles of small affect, as well as rare variants of larger effect (such as copy number variations: CNVs) that contribute to the overall genetic architecture of schizophrenia on a population basis.

Large case-control studies using whole genome arrays of single nucleotide polymorphisms (genome-wide association studies) have identified multiple common risk alleles for type 2 diabetes, many of which reside in or near genes not previously implicated in the pathogenesis of diabetes, 9 10 11 12 in addition to confirming loci identified by previous candidate gene studies.

It is more plausible that there are multiple common low risk (low penetrance) genetic variants, which are associated with relatively small effects on risk in the individual, but contribute substantially to the overall risk in the population (Antoniou et al, 2002).

No genome-wide association studies have been done for FAS or FASD, probably because of the recognition of multiple common environmental risk factors that are difficult to quantify and a paucity of large sample sizes and appropriate controls.

The recent advances in the field of genetic epidemiology have validated the hypothesis that at least part of that remaining missing susceptibility lies in the form of multiple common low-risk variants, each conferring a modest effect on disease risk.

Accordingly, studies have found that the predictive value for T2DM diagnosis can be improved by combining multiple common low-risk variants [9], [10], [11], [12], [13], [14], [15].

Field cancerization [ 30] can explain in part the development of multiple tumors by shared common risk factors, where the carcinogenic effects of alcohol, tobacco and betel nut may simultaneously act on the entire mucosa of mouth, pharynx and aerodigestive tract to trigger the development of multiple cancers that are independent of each other.

Since dental caries is a disease caused by multiple factors, prevention, based on common risk factors plays an important role on caries management [ 43, 44].

Here, we have used a more powerful, genome-wide approach and examined whether, when they are considered en masse using polygenic score analysis, multiple schizophrenia and bipolar disorder common risk alleles contribute to ADHD risk.

As a more general test of the hypothesis that common risk alleles contribute to the multiple adenoma phenotype, we compared the SNP risk score distributions in multiple adenoma cases and controls.