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The data appear to be consistent with the rare haplotypes being derived independently (and by their rarity, we infer recently) from multiple common haplotypes by single genetic events such as nucleotide substitution or deletion of a short segment of DNA.
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Also, there are common haplotypes that are shared between multiple sampling sites.
Estimation of haplotypes in the genes with multiple SNPs resulted in 5, 4 and 3 common haplotypes (i.e. > 1%) for CYP1B1, CYP3A4 and CYP3A5 respectively.
When two independent African-American samples were analyzed, more than half of the sampled HVS-I mtDNA haplotypes exactly matched common haplotypes that were shared among multiple African ethnic groups.
In nuclear datasets in contrast, no geographic structure could be detected in the star-like networks in either genus; the nuclear genes generally possessed one or two common haplotypes that were found on multiple islands.
We identified several common haplotypes to be associated with increased BP and multiple low frequency haplotypes significantly associated with lower BP (>10 mmHg reduction) and risk for hypertension (OR<0.60).
Half of the sub-Saharan mtDNA sequences in our database are common haplotypes that are shared among ethnic groups from multiple regions of sub-Saharan Africa.
Our database of sub-Saharan mtDNA sequences includes the most common haplotypes that are shared among ethnic groups from multiple regions of Africa.
Four of the markers were haplotype-tagging SNPs (htSNPs) that defined five common haplotypes.
Finally, we show that restricting variation discovery to coding regions does not adequately describe all common haplotypes or the true haplotype block structure observed when all common variation is used to infer haplotypes.
We also report that the average number of inferred haplotypes per gene, when complete data is used, is higher than in previous reports and that the number and proportion of all haplotypes represented by common haplotypes per gene is variable.
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CEO of Professional Science Editing for Scientists @ prosciediting.com