Sentence examples for multiple common alleles from inspiring English sources

However, only DRB1*1101 had multiple common alleles with different six-digit designations (i.e., *110101 and *110102) in the study population.

The genetic risk of developing sporadic MPNST could be attributable to multiple common alleles with a low penetrance interacting with each other and/or environmental factors.

Our findings are consistent with the emerging model that at the extremes of a complex genetic trait, such as patients with Fredrickson HLP phenotypes are found the cumulative contributions of multiple common alleles.

This is consistent with the common disease common variant (CDCV) model, which proposes that multiple common alleles each make a small contribution to susceptibility, and may combine, together with environmental risk factors, to cause disease when a certain threshold is reached.

It is now thought that there are both multiple common risk alleles of small affect, as well as rare variants of larger effect (such as copy number variations: CNVs) that contribute to the overall genetic architecture of schizophrenia on a population basis.

Large case-control studies using whole genome arrays of single nucleotide polymorphisms (genome-wide association studies) have identified multiple common risk alleles for type 2 diabetes, many of which reside in or near genes not previously implicated in the pathogenesis of diabetes, 9 10 11 12 in addition to confirming loci identified by previous candidate gene studies.

Late-onset AD might be caused by multiple common or rare alleles, as well as by a wide spectrum of alleles of different frequencies and phenotypic effect sizes.

Although linkage studies have been successful in mapping a number of these key candidate genes [8], studies relying on linkage disequilibrium (LD) have grown in popularity because they can be more effective in detecting weaker associations from multiple common and low-penetrance alleles [13], [14].

Each animal was assigned a new phenotype for which the effect of the DGAT1 SNP from the experimental GWAS was subtracted as a multiple of the number of common alleles present.

Nearly all of the identified alleles differed by multiples of two bases from these common alleles.

Common alleles defined as those observed in multiple individuals.