Sentence examples for multiple colorectal adenomas from inspiring English sources

MAP is a disorder caused by bi-allelic germline MUTYH mutations, characterized by multiple colorectal adenomas.

MUTYH-associated polyposis (MAP) is a disorder caused by bi-allelic germline MUTYH mutation, characterized by multiple colorectal adenomas.

MUTYH has been associated with multiple colorectal adenomas (Al-Tassan et al, 2002) and with colorectal adenocarcinomas (Croitoru et al, 2004; Farrington et al, 2005).

It was first described in 2002 by Al-Tassan et al in a British family with three affected members and recessive inheritance of multiple colorectal adenomas and carcinoma.

Individuals who develop multiple colorectal adenomas (MCRAs) are a genetically and clinically heterogeneous group who are at increased risk of colorectal cancer (CRC).

We recently identified specific germline EDMs in POLD1 and POLE that are causative for the development of multiple colorectal adenomas and CRC.

Fearnhead et al. (36), in 124 multiple colorectal adenoma patients and 483 controls, found 24.9% of cases but only 11.5% of controls carried potentially pathogenic variants in five candidate genes implicated in colorectal tumorigenesis.

MYH polyposis is an autosomal recessive multiple colorectal adenoma and carcinoma disorder caused by inherited defects in the MYH gene (Al-Tassan et al, 2002; Jones et al, 2002; Sampson et al, 2003; Seiber et al, 2003).

Jr Jr Jr The presence of multiple (5 100) colorectal adenomas suggests an inherited predisposition, but the genetic aetiology of this phenotype is undetermined if patients test negative for Mendelian polyposis syndromes such as familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP).

Cases were further classified into multiple distal colorectal adenoma (two or more adenoma) and advanced adenoma (size of ⩾1 cm, high-grade dysplasia, or villous components, including tubulovillous); with some individuals falling into both categories.

Even more unsuccessful was supplementation with folic acid in 1,021 subjects, which increased the risk of recurrence of multiple or larger colorectal adenomas [ 251].