Sentence examples for multiple coagulation factors from inspiring English sources

For instance, how does one evaluate the action of new antithrombotic drugs that only act on specific coagulation factors, whereas current antithrombotic drugs may act on multiple coagulation factors?

Additionally, we found that multiple coagulation factors have been lost in bowhead and minke whales.

However, these tests are a convenient method to quickly estimate the concentration of one or at times multiple coagulation factors for which each test is sensitive (Table 2) [ 27].

It is responsible for the proteolytic cleavage and activation of multiple coagulation factors including Factor V, VIII, XI, as well as fibrinogen and protein C. 1– 2 Thrombin also cleaves and activates protease-activated receptors (PARs) which are highly expressed on platelets, endothelial cells, myocytes, and neurons.

With a single coagulation factor deficiency, an INR of 1.5 represents a clinically important (<30%) reduction in that factor [ 8], but in situations where multiple coagulation factors are affected, such as in critically ill patients, the levels of the individual coagulation factors are sufficient for hemostasis (>30%) when the INR is 1.5 and perhaps even higher [ 8].

Hepatic dysfunction may alter multiple critical coagulation factors which are produced by the liver, which may explain some of the coagulation abnormalities associated with HIV infection.

This beneficial process can be reversed to a life-threatening event during severe inflammatory responses, since excessive thrombosis activation may lead to disseminated intravascular coagulation (DIC) and consumption of multiple clotting factors [57].

Key components of this process have recently been elucidated, involving Ad capsid interaction with multiple vitamin K-dependent coagulation factors [37].

Venom-induced consumptive coagulopathy or VICC [ 42] is characterized by activation of the coagulation pathway and consumption of coagulation factors, mainly fibrinogen, resulting in multiple factor deficiencies in snakebitten patients [ 42– 42].

Multiple factors may play a role: the extracorporeal circuit itself, treatment modalities, platelet factors, coagulation factors, natural anticoagulants and fibrinolysis [ 2, 3].

With no knowledge of blood groups or coagulation factors, the early transfusion experiments were deadly.