Among the most common manifestations are the renal and immune system involvement; the first one is responsible for the majority of the morbidity and mortality of patients, and the second strongly associated with multiple clinical manifestations.
Results include multiple clinical manifestations per patient.
Each patient may have had multiple clinical manifestations of the CNS involvement.
Each patient may have had multiple clinical manifestations of central nervous system involvement.
Each patient may have had multiple clinical manifestations of central nervous system (CNS) involvement.
More survivable cases, occurring with lower infusion rates, have replaced lethal PRIS with multiple clinical manifestations.
Although there are multiple recognized clinical manifestations of IgG4-related sclerosing disease, including sclerosing cholangitis, cholecystitis, retroperitoneal fibrosis, interstitial pneumonia, tubulointerstitial nephritis, and inflammatory pseudotumor [2], gastric lesions are rare.
Fabry disease is a rare metabolic storage disorder that results in progressive effects on multiple organs; clinical manifestations include pain from nerve damage, gastrointestinal symptoms, angiokeratoma, corneal changes, and hearing loss.
While multiple symptoms and clinical manifestations are significantly associated with transmission in the univariate analysis, variables such as oxygen dependency, prior history of co-morbid illness, higher neutrophil counts and lactate dehydrogenase levels are correlated to each other and to disease severity [ 24, 25].
Alström Syndrome [ALMS (MIM #203800)] is a rare, autosomal recessive monogenic disease characterized by a wide spectrum of clinical manifestations involving multiple organs, including blindness, severe insulin resistance, type 2 diabetes, obesity and cardiomyopathy that progressively affects multiple organ systems [1].
The survival, propagation and dissemination of bacteria to multiple organs results in severe clinical manifestations in brain, heart, liver and osteoarticular tissues.
