"It's a drug that's been studied in multiple clinical trials in various indications," says Dr. Howard Hutchinson, AstraZeneca's chief medical officer.
Clinical indications for multiple balloon inflations in the IRA were: long or multiple lesions requiring >1 pre-dilatation, the placement of ≥2 stents or the need for >1 post-dilatation.
Using multiple scan protocols for different clinical indications and patient groups (e.g. obese patients) for the same CT region will disperse the CT-dose levels.
As noted above, IFN-β 1a is currently being used for a variety of clinical indications, including multiple sclerosis, and has shown dose-dependent efficacy in several clinical trials.
Multiple testing, cumulative radiation dose, and clinical indications in patients undergoing myocardial perfusion imaging.
"Multiple testing, cumulative radiation dose, and clinical indications in patients undergoing myocardial perfusion imaging". Einstein AJ, Weiner SD, Bernheim A, Kulon M, Bokhari S, Johnson LL, Moses JW, Balter S. JAMA.
Summarizing the results of multiple clinical studies on all three Infuse indications, it was stated that "on-label" use of the product is safe and effective in most cases, although there is a definite possibility of complications, as well as unsatisfactory results requiring resurgery.
Multiple classification systems have been proposed, based on clinical indications, "degree of urgency", or patient characteristics, but none have been extensively implemented [ 33].
While the efficacy and safety profile of ranibizumab in licensed indications has been demonstrated in multiple clinical trials, 1 9 the safety profile of intravitreal anti-VEGF therapies in routine clinical practice remains less well established.
