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Finally, using immunohistochemistry, we validated the prognostic utility of PML in 254 additional cases of GIST from multiple clinical facilities.
Immunohistochemistry of 254 additional cases from multiple clinical facilities showed that PML-negative cases were significantly frequent in the I-GIST group (P < 0.001).
Using additional cases from multiple clinical facilities, we successfully validated the association of PML downregulation with I-GIST and a shorter RFS period.
We validated the association of PML expression with the tumor site and confirmed its prognostic utility in additional cases of GIST from multiple clinical facilities using immunohistochemistry. Downregulation of PML expression was significantly associated with not only I-GIST, but also a larger tumor size, higher mitotic count and higher risk of recurrence (Table 3).
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An inventory of hand hygiene facilities was conducted over both sites in multiple clinical areas on two separate occasions by two researchers RM and DB.
Particularly in facilities where health personnel are understaffed or have multiple clinical responsibilities, one alternative may be to explore the feasibility and effectiveness of expanding the role of less skilled health workers who may have fewer time constraints.
Each of the sites was observed for a minimum of 8 hours; the research nurses attempted to observe multiple clinical units (e.g., medical-surgical floor, ICU) at each facility.
The center was designed as a virtual hospital with multiple clinical in-hospital care environments including emergency rooms, operating rooms, intensive care units, and outpatient facilities.
Singapore has a diverse ethnic composition, world-class clinical facilities, and excellent clinical data management.
The few surviving clinical facilities were overwhelmed with critical cases.
Multiple clinical testing proved this basic premise correct.
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CEO of Professional Science Editing for Scientists @ prosciediting.com