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The ABS metric was calculated for each simulation, and the multiple chromosome structure of the data were mimicked by sampling each individual repeatedly with different data densities.
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We followed the approach suggested [ 63] and applied to this multiple trait and multiple chromosome testing issue [ 43] using a canonical transformation of traits based on phenotypic correlation structure, to estimate the number of independent variables being tested.
The wide distribution of events argues that the dicentric breaks occur at some common element of chromosome structure (for example, a promoter or other nucleosome-free region) or that the breaks are associated with multiple different types of chromosome elements.
Higher order chromosome structure is mediated by a conserved set of protein complexes called SMC for structural maintenance of chromosomes.
In: Chromosome Structure and Function.
Nicodemi, M. & Pombo, A. Models of chromosome structure.
Higher Order Chromosome Structure is important for the integrity, transmission and expression of chromosomes.
Higher order chromosome structure is important for transcription, chromosome segregation and DNA repair.
Carlton, P.M. Three-dimensional structured illumination microscopy and its application to chromosome structure.
These somatic changes in chromosome structure include duplication of entire chromosome arms and aneuploidy where chromosomes are duplicated beyond normal diploid content.
And that's because in people the chromosome structure is far more complicated.
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