Sentence examples for multiple chromosomal sites from inspiring English sources

Our results strengthen LOH studies (Kitamura et al, 2001) carried out in ATC that showed frequent allele loss at multiple chromosomal sites in this carcinoma type.

The efforts to allelotype breast cancer showed concurrent loss of heterozygosity (LOH) at multiple chromosomal sites, with LOH at 16q being one of the most common events (52.3%) in sporadic breast cancer [ 27].

Our strategy is designed to compensate for the inherent disadvantage of loss of gene dosage (vs. plasmid-based expression) by integrating antigen-encoding gene cassettes into multiple chromosomal sites already inactivated in an attenuated Salmonella enterica serovar Typhi vaccine candidate.

No Tra island or ICE in mycoplasmas has been directly shown to mediate conjugative transfer, however some (including Tra II) are known to exist in extra-chromosomal forms and to integrate at multiple chromosomal sites [ 72, 75, 76].

With the exception of rare monogenic disorders, most type 2 diabetes results from the interaction of genetic variation at multiple different chromosomal sites with environmentalexposures experienced throughout thelifespan (1).

The high efficiency of insertion allows gene disruption without the introduction of an antibiotic marker into the chromosome and the efficient sequential creation of multiple knockouts at disparate chromosomal sites.

Comparative molecular cytogenetic analysis in the Rosaceae will benefit from the development of additional probes targeting conserved sequence sites at multiple chromosomal locations.

The lipid methylene signal (1.22 ppm) showed correlations with polymorphic sites at multiple chromosomal locations, with the highest located around the C43 RFLP marker at 92.8 cM on Chr. 5 (rs = 0.66, P < 0.01), and the second highest around R1943 at 123.7 cM on Chr. 8 (rs = 0.58, P < 0.01).

In "stable" transfections, the transfected DNA typically inserts as an array of multiple copies; the insertions occur at undefined and irreproducible chromosomal sites, the copy number varies idiosyncratically, and the multiple copies are in both orientations.

Thus, synergistic action of site mutations in multiple chromosomal genes associated with resistance in N. gonorrhoeae isolates is an important subject for investigation.

"Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5". Oncotarget 5 (21): 10596-10606.