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The developed CEC MS method has the potential to emerge as a screening method for analysis of multiple chiral compounds using a single protocol using the same column and mobile phase conditions, thus reducing the operation time and cost.
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As in the case of compounds with multiple chiral centers, the generation of a unique double bond descriptor for compounds with multiple double bonds having certain symmetry elements can be complicated.
The pharmaceutical industry demands a speed of development that must be on a parallel with conventional chemistry and high optical purity for complex compounds with multiple chiral centres.
2-Deoxy-d-ribose-5-phosphate aldolase (DERA) belongs to the family of lyases and can form C C bonds to generate multiple chiral centers, thus providing an interesting route to produce key chiral compounds.
Many optically active tricoordinate compounds occur in nature, and optically active sulfur compounds are widely used in the synthesis of other chiral compounds.
Notably, chiral compounds exhibit stereoselective activity.
Pyrimidine-based chiral compounds were successfully synthesized via Mitsunobu reaction.
A practically endless list of chiral compounds provided by nature can be compiled.
Subsequent extensions tried to tackle the lack of discrimination between chiral compounds [9, 10].
Also, the binding is associated with the enantioselective interaction between plasma protein and chiral compounds.
Hence lipases can be used for the resolution of various chiral compounds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com