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Complex polyketides are characterized by multiple chiral centers harboring hydroxyl and alkyl substituents.
2-Deoxy-d-ribose-5-phosphate aldolase (DERA) belongs to the family of lyases and can form C C bonds to generate multiple chiral centers, thus providing an interesting route to produce key chiral compounds.
At the same time, sugars are characterized by specific and very sensitive structural features such as multiple chiral centers on each ring.
They showed the separation of ephedrine and pseudoephedrine-containing multiple chiral centers by coupling CEC to MS (He, Wang, Morill, and Shamsi, 2012).
While treatment of structures with multiple chiral centers in the MCDL is straightforward in many cases, the presence of multiple chiral centers in certain quasi-symmetrical structures may lead to complications due to the fact that the unique part of the MCDL linear descriptor is generated without consideration of stereochemistry.
As in the case of compounds with multiple chiral centers, the generation of a unique double bond descriptor for compounds with multiple double bonds having certain symmetry elements can be complicated.
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Unlike known salen ligands, of which chirality originates from central and axial chiral centers, the chirality of this ligand comes from the planar chiral ferrocenyl groups.
Chiral drugs are a subgroup of drug substances that contain one or more chiral centers.
Stereogenic properties of compounds having chiral centers were discussed.
Carbon carbon bond formation involves forming two adjacent chiral centers.
The chiral centers in the P4 fragment were constructed by an asymmetric chelated Claisen rearrangement in the presence of quinidine as the chiral ligand.
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