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Few models exist to adequately examine the combined effects of multiple chemicals with potential endocrine activity.
We should expect effects to be due to multiple chemicals with varying half-lives, metabolism, persistence, tissue accumulation and target sensitivities; complete analysis will require a mixtures approach.
The vast array of chemicals present in the environment means wildlife may be exposed to multiple chemicals with the potential to cause adverse effects via various physiological routes.
Mixture modeling uses single compound testing data to describe the effects of simultaneous exposures to multiple chemicals, with the aim of replacing or significantly reducing testing for the prohibitively large number of chemicals and combinations present in the environment.
As defined, aggregate exposure is the extent of contact and exposure of a defined population to a given chemical by all relevant routes and all relevant sources, and cumulative exposure is the extent of contact or exposure of a defined population to multiple chemicals with common toxic effects found in at least one media and one or more sources (U.S. EPA 2001, 2003).
Similar(54)
It became clear that human fetuses were contaminated with multiple chemicals in Japan.
However, before HTS can be confidently applied to mixtures, additional chemistry requirements associated with multiple chemicals in a small volume must be addressed.
However, possible contamination with multiple chemicals in the N-methyl carbamate class only slightly increased the risk of PD, if at all (the 95% CIs included the null), and we observed no trend with increasing numbers.
The sensor demonstrated a rapid response time with portability, accuracy and versatility for the in situ detection of multiple chemical agents, with potential for automation.
For the first time, we have customized CIRCOS [29] (http://circos.ca/) to visualize multiple chemical properties with biological activity and obtain clusters for near neighbour analysis.
This study can be helpful to both determination of the potential air-quality impact for geographic distribution of multiple chemical plants with respect to regional statistical meteorological conditions, and the identification of an optimal site for each new chemical manufacturing site with the minimal environment impact to surrounding communities.
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