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Reliability methods, such as Standard Monte Carlo (SMC), Monte Carlo with Importance Sampling (MC IS), First Order Reliability Method (FORM) and FORM with Multiple Check Points (FORM MCPs) are used to compare the solution and the processing time when the Finite Element Method (FEM) is employed and when the finite element analysis (FEA) is substituted by trained artificial neural networks (ANNs).
Additional strengths include training and utilization of multiple check points to ensure quality data collection, data entry and interpretation.
The overall logic of the process appears to be largely directed at ensuring the processes of chromatin disassembly and reassembly are tightly coupled with transcription in a fashion that is comparable with the cell cycle where multiple check points ensure regulated progression with the single outcome of duplication.
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The transition from quiescence to proliferation is exquisitely controlled by multiple check-points and fail-safe mechanisms, but is still susceptible to deregulation if the signaling pathways involved are sufficiently perturbed.
Major check points are controlled by multiple protein kinases, such as cyclin component and a catalytic cyclin-dependent kinase (CDK) [ 4, 5].
Irradiation of cells causes macromolecular damage (viz DNA, protein etc) stimulating multiple signaling pathways viz DNA repair, cell cycle check points, apoptosis and senescence that collectively determine the fate of cells [ 22].
Soldiers and check points were everywhere.
b Displacement error map at check points.
During this transit, multiple processes must be coordinated, including folding, specific proteolytic cleavage, glycosylation, and disulfide bond formation, all with a layer of quality control at key check points.
Gates serve as quality control mechanisms and check points [ 21].
Mouse embryonic fibroblasts carrying targeted deletion of BRCA1 gene were defective in a G2-M check point leading to multiple spindle poles within a single cell resulting unequal segregation of chromosomes, abnormal nuclear division and aneuploidy [ 5].
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