To study the response of M. balthica to multiple changes occurring in the benthic environment, we conducted an experiment to investigate the survival and shell growth of newly settled juveniles simultaneously exposed to two pH levels (7.85 and 7.35) and two oxygen levels (8.5 and 3.0 mg/l) for 29 days in a fully factorial design.
These multiple changes occur in the pathway towards H2A.Z-1, further illustrating the less constrained status of this variant compared to H2A.Z-2.
Although multiple changes occurring at the same amino acid position among five strains of B. subtilis (i.e., multiple hits) may reflect diversifying positive selection, they may also have happened simply by chance, because the chance probability of such events is not low.
As there are long development times, multiple design changes occur frequently because of changes in requirements.
Multiple genetic changes occur during the evolution of normal cells into cancer cells.
First, in naturalistic reproductive hormone fluxes, such as puberty, the menstrual cycle, pregnancy, lactation and menopause, multiple hormonal changes occur simultaneously".
In addition, it has been shown that multiple biochemical changes occur in prion protein knockout mice.
With advancing age, multiple physiological changes occur in the body, altering the pharmacodynamics and pharmacokinetics of drugs.
In natural field populations, many traits are under selection and genetic correlations among them may limit or constrain adaptation when multiple environmental changes occur.
To fertilize an oocyte, multiple extreme changes occur in spermatozoa that begin from its formation in the testes of the male reproductive tract to its penetration and fusion with an egg in the female reproductive tract.
