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During the generation of iPSC, multiple changes have been observed with the MEF, including those in gene expression profiles (Brambrink et al., 2008), epigenetic state (Koche et al., 2011; Watanabe et al., 2013), cell morphology (Li et al., 2010; Samavarchi-Tehrani et al., 2010), and cellular metabolism (Folmes et al., 2011).
Multiple changes have been described in the ageing heart that impact on its ability to tolerate stress [ 5], and this may result in the gradual unmasking of the functional phenotype over time.
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Also, the benefits of multiple lifestyle changes have not been carefully examined.
Multiple genetic changes have been found in NPC, with frequent deletion of regions on chromosomes 3p, 9p, 11q, 13q, and 14q and promoter hypermethylation of specific genes on chromosomes 3p (RARβ21andRARβ2) and 9p (p15, p14, p14, DAP-kinase) [80], [81].
Nuclear reactor operating modes under multiple cyclic power changes have been promoted recently, and fuel element cladding behavior under the multiple cyclic power changes has been widely known as a key issue in terms of rod design and reliability.
The aim of this article is to understand what kinds of meanings VET teachers attribute to the multiple changes that have occurred in VET over the last two decades, how they have responded to them (which activities they have implemented to cope with changes) and what are/have been the consequences for teacher professionality.
In the models using any physico-chemical evaluation of selective constraints, the significance of multiple nucleotide changes has been indicated; see Tables 2 and 3.
This gives some cause for concern when you recognise the multiple changes that have been imposed on the management of schools over the past 15 years - in practice, three generations of secondary-school pupils.
The higher level of drop in expression observed in the present study could be due to the multiple changes that have been carried out rather than changes in one or two bases.
Figuring this out isn't straightforward, as interest rate changes have multiple impacts on commercial real estate (CRE).
Multiple rounds of rule changes have occurred in efforts to gin up scoring and make it easier for offenses to pass the ball.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com