However, in a physiological situation where multiple Ub chain linkages are often mixed, substrate-targeted DUBs may cleave additional Ub chain types.
Drayson, M. et al. Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials.
Small, weldless chain types include knotted chain, stamped-link chain, bead chain, and jewelry chain; these find use in electric fixtures, key chains, jewelry, and other small articles.
Times Square is, essentially, a chain restaurant containing multiple chain restaurants, surrounded by digital screens running advertisements for the chain restaurant equivalents of news, products, and services.
Two Multiple Chain Markov Chain Monte Carlo (MC) searches were conducted with four chains each (three heated and one cold).
The chain type consists of multiple rigid bodies and connections such as a tractor-trailer.
Ub chains bearing multiple linkage types coexist in the cell, and the level of each chain type is regulated by DUBs that selectively hydrolyze Ub linkages.
Phos-tag gels of reactions using Lys63-linked triUb as substrate resulted in multiple bands and diffuse signals, suggesting that more than one Ub molecule can be targeted by PhPINK1 in this chain type (Supplementary Fig S1B, C and E).
Given that running multiple chains is simple and that they scale well with the number of available processors (or CPU cores), this type of "multiple-chain" parallelism is usually the strategy to strive for in the first instance.
The intuition is that by running multiple chains exploring different modes and enabling between chain jumps, essentially each chain would jump between modes efficiently.
