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The Genetics of Sepsis and Septic Shock in Europe (GenOSept) and Genomic Advances in Sepsis (GAinS) are prospectively gathered cohorts of critically ill septic patients with FP recruited from multiple centres in Europe.
We also contacted the authors if papers reported collective data from multiple centres in order to obtain disaggregated data.
These factors, taken with the large size and multiple centres in the ROSSINI trial would suggest the findings are robust.
The strengths of this study include its randomized, double-blind, placebo-controlled design, and the enrolment of both children and adolescents at multiple centres in Europe.
Two studies met the inclusion criteria (MEM-MD-02 and MEM-MD-12), both of which were performed in multiple centres in the US [ 16, 17].
13 A major strength of this study is that we collected all data prospectively, from multiple centres in an international setting.
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Therefore, we used the pragmatic approach of comparing treatment to usual care, permitting additional treatment points as well as standard treatment points, and using patient-centred outcomes in multiple centres.
Selecting participants from multiple centres and locations in the Netherlands allows us to include a representative selection of breast cancer patients.
Finally, although multiple centres were included in this study, more than one-half of the patients were enrolled from two ICUs with small numbers included from some sites, limiting the ability to assess inter-facility variability.
23 Two studies were in multiple centres 24 25 and three were studies in single centres.
In one study conducted in multiple centres with low losses to follow-up, 20% of patients reported an unfavourable pain outcome at follow-up.
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