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Although the condition is still relatively uncommon in the USA, recent studies have shown an increasing number of cases in both contact lens wearers and non-contact lens wearers at multiple centers across the country [2].

The majority of the SNPs used on the PorcineSNP60 Beadchip were discovered in commercial European and US breeds and this ascertainment bias has to be taken into account when using the chip for some applications, especially when considering that domestication of pigs originated from multiple centers across Europe and Asia [26].

Briefly, participants with a diagnosis of full trisomy 21 were enrolled through multiple centers across the United States.

Proby et al. 13. included 210 cases and 394 control transplant recipients from multiple centers across Europe.

Results from over 50 patients with refractory JIA who have undergone autologous stem cell transplantation at multiple centers across Europe have been published [ 46, 47].

In an important Phase I/II study, 140 men with progressive CRPC were enrolled at multiple centers across the United States.

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This will require validation in larger studies with concurrent controls, across multiple centers, and across several disease-types.

Furthermore, research networks facilitate the recruitment of participants across multiple centers and countries and allow for the validation of findings across settings [ 2].

This will make it possible to carry out queries such as 'which mutations are significantly more frequent in clinical population A versus clinical population B across multiple centers?' The key concept in NGS-Logistics is to let users query SNVs across data sets in multiple centers.

Scholars have suggested that the governance of complex systems should be dispersed across multiple centers of authority and that any regulative system needs as much variety in the actions that it can take as exists in the system it is regulating.

PCA was also used by Waring et al. [5] to illustrate the reproducibility of microarray data across multiple centers.

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