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We suggest that larger cohort studies or multiple center studies are needed to validate whether acupuncture is another effective stimulation pattern to activate the cholinergic anti-inflammatory pathway.
In multiple center studies where a prediction model is developed from one center to predict patients of another center, comparing the medians of training and test scores will be useful to understand the underlying survival distributions of the two centers.
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42 This was a multiple center study with subjects of Caucasian skin types I II and Asian skin type III IV.
In a large, multiple center study by Vincent et al., admission type of patients were elective surgery (41.4%), medical (32.6%), emergency surgery (16.6%), trauma (7.6%) and other (1.6%) [ 2 ].
Thus, multiple-center studies will be necessary to validate our conclusions.
In the ICU setting, only four multiple-center studies using the RIFLE criteria have been published so far [ 10- 13].
Three multiple-center studies using conventional statistical models found an association between RIFLE class and mortality [ 10, 11, 13].
Multiple-center studies have shown that CCTA allows reliable detection of coronary artery stenoses with high sensitivity and specificity as compared to conventional coronary angiography [ 2, 3].
Garrouste-Orgeas Garrouste-Orgeas MiMontuclardet aL, (2005) PredicTimsitf intensive care unit refusal in French intensive care units: a multiple-center study.
2. Jaber S, Amraoui J, Lefrant JY, et al. Clinical practice and risk factors for immediate complications of endotracheal intubation in the intensive care unit: a prospective, multiple-center study.
Jaber S, Amraoui J, Lefrant JY, Arich C, Cohendy R, Landreau L, et al. Clinical practice and risk factors for immediate complications of endotracheal intubation in the intensive care unit: a prospective, multiple-center study.
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