One example is the E3 ubiquitin ligase Nedd4 (neural precursor cell-expressed developmentally downregulated 4) family known to regulate trafficking and endosomal degradation of multiple target substrates within different cellular environments (reviewed in [ 74]).
Using a microarray containing approximately 18,400 human mRNA transcripts, we found several alterations after the expression of Tax proteins in genes involved in many cellular functions such as transcription, signal transduction, cell growth, apoptosis, stress response, and immune response, indicating that Tax protein has multiple biological effects on various cellular environments.
In general, the dynamics of a regulatory network depends on multiple factors such as initial conditions, cellular environments, and randomness [ 34, 35].
The third consideration was to investigate miRNA function in multiple cell types to gain insight into how specific cellular environments may influence the profile of genes a specific miRNA may or may not have the capacity to influence.
Understanding the complexity of the cellular environment will benefit from the ability to unambiguously resolve multiple cellular components, simultaneously and with nanometer-scale spatial resolution.
This malarial parasite has a lifecycle that alternates between a human host and mosquito vector, requiring multiple morphological and biological adaptations to successfully invade, colonise and divide within diverse cellular environments.
Multiple false positive results occur in gene prediction, and the targets of certain miRNAs may be altered in different cellular environments; therefore, we overlapped the prediction results with the mRNA-seq results.
Hydrophobins, proteins with multiple cellular functions, might also have important roles in fortifying the cell wall of W. ichthyophaga against the hostile environment, as indicated by genomic and transcriptomic analyses.
The sustainability of a malignant tumour requires multiple cellular events by which the cancer cells acquire growth factor independence, escape cellular apoptosis mechanisms, create a self-sustaining environment and escape the neighbouring barriers by migrating and colonising to a distant site (Hanahan and Weinberg, 2000).
Lymphocytes exist within highly organized cellular environments.
