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Most serious diabetic complications are mediated by the free radicals, which damage multiple cellular components through direct effects of the cell cycle regulatory proteins.
Avocado mesocarp treated to deplete oil content showed reduced 1-MCP sorption rate and capacity whereas the exocarp was negligibly affected, indicating that multiple cellular components contribute to non-specific sorption.
Complex interactions between multiple cellular components underlie synaptic transmission, a process that occurs with speed, precision and plasticity for extended periods of time.
Simultaneous image analysis of multiple cellular components requires multicolor labeling, quantitative imaging of each individual label, pixel-by-pixel composition analysis, and visualization.
Indeed, oxidative stress is known to be a common underlying mechanism in the pathogenesis of many neurodegenerative diseases causing damage to multiple cellular components such as DNA, proteins and lipids [27], [28].
Since neurotransmitter release relies on complex interactions between multiple cellular components, we speculate that the cross-talk between CSPα chaperone machinery and the stress-induced Hsp40 is important in maintaining functionally competent synapses.
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Moreover, association of multiple cellular component GO terms would not specify which domain of the protein would be located in which cellular compartment.
Using the existing Pathway Tools framework, we could indicate that different parts of a protein acting as an enzyme were localized to different cellular compartments by associating multiple Cellular Component Gene Ontology terms with the corresponding protein frame.
Also, the Pathway Tools framework can incorporate sub-cellular localization information about any enzyme or transporter by allowing the association of one or multiple Cellular Component Gene Ontology terms with the corresponding protein frame.
To globally map networks that control lipid metabolism in yeast, we applied a systems approach integrating measurements across multiple cellular component layers (mRNAs, lipids, metabolites) and data from protein interaction databases with metabolic network topology.
The cell responses to HAMLET were rather complex, involving multiple cellular organelles or components, such as mitochondria, histone, proteasomes, which were shown to interact with HAMLET inside the cells.
More suggestions(15)
several cellular components
multiple cellular processes
multiple cellular steps
multiple cellular subsets
multiple cellular compartments
multiple cellular pathways
multiple connected components
multiple cellular conditions
multiple chemical components
multiple cellular proteins
multiple cellular sites
multiple cellular targets
multiple cellular functions
multiple cellular changes
multiple cellular events
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