Although celltrapping devices have been microfabricated and widely used for manipulation of bio cells, devices that trap multiple cells simultaneously are difficult to design because fabrication is complicated and time consuming.
This mutant was phenotypically different from the pen1-1 because death in the mutant seedlings occurs in multiple cells as compared to in single cells in the pen1-1 mutant.
Because several of the point mutants decreased but did not abolish transcriptional reporter activity in multiple cells, selected combinatorial point mutants were generated and tested in SW480 cells.
Because injectable backpacks are free to attach to cells in many different configurations, including multiple cells per backpack and vice versa, cell−backpack aggregates form.
Sorting out the effects of VEGF inhibition on the tumour microenvironment poses challenges because multiple cell types within the tumour microenvironment express VEGFRs.
Performing large numbers of functional screens using different combinations of multiple cell surface markers is virtually impossible because stem cell transplantation is required to validate stem cell function.
Errors in this approach could potentially arise because of the multiple cell types in the animal expression experiments or the arbitrary cutoffs utilized in the statistical filters.
Laminin proteins have been proposed as hPSC culture surfaces due to their prominence in more complex surfaces [ 52] and because they contain multiple cell-binding motifs including RGD, E8, IKVAV, AG-10, C-16 and AG-73 [ 55, 56] that interact with various integrins and proteoglycans expressed by hPSCs [ 57].
Our data provide evidence that VSV undergoes multiple rounds of copying per cell because, although most of the 496 mutations were unique, 147 were found in two or more plaques derived from the same cell, showing that the mutation was copied during viral replication within the very first infected cell.
Research to create new lungs in the lab has lagged because of their complex structure and multiple cell types, notes biomedical engineer Laura Niklason of Yale University.
