Sentence examples for multiple cell survival from inspiring English sources

Those events especially lead to dysregulated apoptosis and constitutively activation of multiple cell survival pathways.

MET promotes tumour growth, angiogenesis and activates multiple cell survival signalling pathways (Xiao et al, 2001; Birchmeier et al, 2003; Derksen et al, 2003; Garcia et al, 2007).

G-CSF is a cytokine known to be involved in multiple cell survival, proliferation, and invasion related pathways, but its role in GI cancers has not been examined.

Combination therapy might promote synergistic effects leading to low drug dosage, as well as suppresses resistance to therapy if multiple cell survival pathways are targeted at once though there are chances of higher toxicity.

Oncolytic viruses carry great potential as broadly active cancer therapeutics, as they simultaneously interfere with multiple cell survival signaling pathways and trigger inflammatory responses, which, in turn, may expose the tumors to the immune system.

Epidermal growth factor receptor (EGFR) is often hyper-activated in many lung cancers due to the presence of a mutation in the kinase domain, causing the activation of multiple cell survival signals, especially Akt and mitogen-activated protein kinase (MAPK) pathways.

Moreover, changes in global proteasome activity underlie multiple cell-survival mechanisms, some of which involve increased proteasome function, whereas others require reduced activity.

Recently, multiple myeloma cell survival was shown to rely on the high activity of protein kinase CK2 [7].

Iron is an essential co-factor for enzymes which regulate multiple cell functions, including survival [ 1– 3].

Survivin is the smallest member of the IAP family and has multiple functions in cell survival, mitosis and proliferation.

Multiple factors affect cell survival, including hypoxia and inflammation, which are known to modulate the balance between EC apoptosis and survival.