Sentence examples for multiple cell signalling from inspiring English sources

This multi-mode action of miR-34 provides a therapeutic advantage over the siRNA-based therapies in that miR-34 has multiple targets, can work on multiple cell signalling pathways at the same time, leading to synergistic effects which may translate into improved clinical efficacy for pancreatic cancer patients with p53 deficiency and advanced disease.

They deregulate cell cycle progression, induce apoptosis, function as antioxidants, modulate multiple cell signalling pathways and inhibit tumor invasion [ 8].

Plitidepsin is a compound with high pleiotropicity, affecting multiple cell signalling pathways and targets (Munoz-Alonso et al, 2009).

Curcumin has anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic properties by regulating multiple cell signalling pathways, including the STAT3 pathway (Aggarwal and Shishodia, 2006).

Plants are rich source of phytochemicals such as carotenoids, resveratrol, quercetin, silymarin, sulphoraphane, and indole-3-carbino that protect from chronic diseases and usually target multiple cell signalling pathways [ 15].

The search for signature genes of different cancers has shown that most cancers are due to dysregulation of multiple genes and multiple cell signalling pathways; thus, drugs that are multi-targeted (once called "dirty drugs") are needed.

Recent evidence supports and expands this idea by demonstrating that mitochondria are an integral part of multiple cell signaling cascades.

These off-target effects involve induction of autophagy and necrotic cell death as well as modulation of the cell cycle and multiple cell signaling pathways.

Also, flavonoids are found to have an effect on several mammalian enzymes like protein kinases that regulate multiple cell signaling pathways and alterations in multiple cellular signaling pathways are frequently found in many diseases.

Another aspect of QCT-inspired synthesis is inositols, especially on myo-inositol and its derivatives because of their important role in multiple cell signaling pathways, such as PtdIns 4, 5 P2 hydrolysis and PtdIns 3, 4, 5 P3 synthesis.

The three cells are induced by multiple cell signaling pathways to adopt vulval cell fates.