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The developed NIR PKA and JNK biosensors enable multiplexing with blue-green optogenetic tools for probing and monitoring of multiple cell processes for better understanding of mechanisms that mediate regulation and specificity of PKA and JNK kinases.
Mitochondrial metabolism is closely involved in multiple cell processes in immune system (MacIver et al., 2013), so we sought to understand whether Hcy-altered mitochondrial metabolism contributed to Hcy-induced T-cell activation.
For example, poly ubiquitins linked with Lysine-48 provide the main targeting signals for proteasomal degradation, whereas polyubiquitins linked with Lysine-63 enable the substrate protein to function as scaffolds to recruit other partners and thereby to participate in multiple cell processes, such as kinase activation, DNA repair, and protein synthesis (Schwartz and Ciechanover, 2009).
The cytosol has no single function and is instead the site of multiple cell processes.
MicroRNAs alter multiple cell processes and thus influence tumour carcinogenesis and progression.
The inactivation of p53 by E6 affects multiple cell processes including apoptosis, cell cycle arrest, cellular differentiation, and senescence [ 50].
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It has been generally accepted that LIN-12/Notch signaling is involved in multiple cell specification processes.
The NOTCH signaling pathway plays an important role in cell-to-cell communications that regulate multiple cell differentiation processes during embryonic and adult life [ 45].
Fibronectin is a large (∼500 kDa) glycoprotein found in a fibrillar state within the extracellular matrix of a great variety of tissues and guides multiple cell physiological processes, from cell adhesion and proliferation to differentiation [1 3].
Another protein Na+/H+ exchanger 7 (UniProt ID: Q8BLV3) is an ubiquitous ion transporter that serves multiple cell physiological processes such as intracellular pH homeostasis and electro neutral exchange of protons for Na+ and K+ across endomembranes.
For this purpose, we used the well-acclaimed animal model Drosophila melanogaster, and we showed that the Atg6, UVRAG, and Vps34-containing PI3K (III) complex is required for multiple cell biological processes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com