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Using multiple cell line models of GBM, it was determined that expression of E-cadherin correlated with growth, migration, and invasiveness.
Resistance to ABT263 treatment has been associated to MCL1 expression in multiple cell line models.
Integration of multiple cell line ESR1 ChIP datasets also increases overlap with ESR1 ChIP-seq peaks from primary cancer samples, further supporting this approach as helpful in identifying true positive ESR1 binding sites in cell line systems.
Notably, use of the PRE as a probe in EMSA showed evidence of DNA-protein interaction with this sequence in multiple cell line nuclear extracts and in mouse brain tissue nuclear extract [ 27].
To reduce variability and facilitate multiple cell line and drug combinations, dose response and drug combination experiments were carried out in 96-well plate format using an automated, high throughput system.
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The antimitotic effect of TTFields therapy has been demonstrated in multiple cell lines when the appropriate frequency was utilized.
Here, we use an approach to analyze TF colocalization within a cell type and across multiple cell lines at an unprecedented level.
Amniotic fluid cells of human origin proliferate rapidly and are multipotent with the potential for expansion in vitro to multiple cell lines.
Using virus or transposon vectors, transgene integration sites and copy numbers are difficult to control, and nearly impossible to reproduce across multiple cell lines.
In addition, presence of histidines along with 9 arginines and secondary amphipathicity shows efficient DNA delivery with low toxicity even in absence of chloroquine in multiple cell lines.
Expression of putatively networked homologous transcripts was analyzed in multiple cell lines and tissues from mouse and human to validate the technique.
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