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Toxic and infestation-induced, genetically engineered and cell implantation rodent models have been generated, contributing to a deeper understanding of the complex cell biology of the tumor, sustained by multiple cell interactions and driven by a huge variety of molecular perturbations.
The multiple cell interactions promoted by ALCAM are due to the five extracellular binding domains Ig-like, which explain the membranous expression pattern revealed by immunohistochemistry (IHC).
In vitro models usually afford greater ability to manipulate cells and examine molecular and cellular mechanisms but they often lack the three-dimensional architecture and the multiple cell interactions present in the bone-tumor microenvironment.
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Our nanofiber yarn-based biotextiles have significant potential to be used as engineered scaffolds to synergize the multiple cell interaction and mechanical stimulation for promoting tendon regeneration.
None of these techniques support real long-term studies including cell proliferation and also offer limited possibility to study, e.g. migrational behavior and multiple cell-cell interactions.
Redundant mechanisms for PBMC activation are most likely due to multiple cell-cell interactions of different cell type which can occur in PBMCs.
The development of integrated cardiovascular tissue is the result of multiple cell to cell interactions involving temporal and spatial events under genetic control.
Among these, microfluidic technologies hold many advantages in terms of their unique ability to capture the essential features of multiple cell type interactions in three-dimensions while allowing tight control of the microenvironment and real-time monitoring.
These processes require multiple cell-ECM interactions and depend mainly on the integrin-ECM interactions and on extracellular proteases-ECM interactions.
Innate immunity plays a significant role in regulating pathogen clearance through multiple types of cell interactions, providing the first line of defense during early stages of inflammation.
The syndecans are the major family of transmembrane proteoglycans in animals and are known for multiple roles in cell interactions and growth factor signalling during development, inflammatory response, wound-repair and tumorigenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com