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Our nanofiber yarn-based biotextiles have significant potential to be used as engineered scaffolds to synergize the multiple cell interaction and mechanical stimulation for promoting tendon regeneration.
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Toxic and infestation-induced, genetically engineered and cell implantation rodent models have been generated, contributing to a deeper understanding of the complex cell biology of the tumor, sustained by multiple cell interactions and driven by a huge variety of molecular perturbations.
The multiple cell interactions promoted by ALCAM are due to the five extracellular binding domains Ig-like, which explain the membranous expression pattern revealed by immunohistochemistry (IHC).
In vitro models usually afford greater ability to manipulate cells and examine molecular and cellular mechanisms but they often lack the three-dimensional architecture and the multiple cell interactions present in the bone-tumor microenvironment.
None of these techniques support real long-term studies including cell proliferation and also offer limited possibility to study, e.g. migrational behavior and multiple cell-cell interactions.
Redundant mechanisms for PBMC activation are most likely due to multiple cell-cell interactions of different cell type which can occur in PBMCs.
The development of integrated cardiovascular tissue is the result of multiple cell to cell interactions involving temporal and spatial events under genetic control.
Among these, microfluidic technologies hold many advantages in terms of their unique ability to capture the essential features of multiple cell type interactions in three-dimensions while allowing tight control of the microenvironment and real-time monitoring.
These processes require multiple cell-ECM interactions and depend mainly on the integrin-ECM interactions and on extracellular proteases-ECM interactions.
These methods are similar in that they compare patterns of regulatory activity across multiple cell types to predict interactions between enhancers and genes.
This suggest that different cell types show different autophagic responses, illustrating the advantages of studying the infection process in a whole animal model, in which multiple cell types and their interactions can be studied at the same time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com