None of them had been on earth long enough for multiple cell divisions to have snipped away at their telomeres.
A differentiating apical compartment grows by tip extension and starts synchronous, multiple cell divisions into a developmentally controlled form [40]. Again, there is the participation of FtsZ, which leads to sporulation septa and then these pre-spores assemble thick spore walls by depositing actin [41].
The mucosal cells are the differentiated villus cells that have undergone multiple cell divisions.
Clonal heterogeneity implies that expression can persist in different states through multiple cell divisions.
In this way we were confident that these colonies represented multiple cell divisions.
First, the loss of repressive epigenetic marks like CpG methylation is a passive mechanism, requiring multiple cell divisions.
The stability of X inactivation ensures long-term maintenance of silencing through multiple cell divisions and throughout the lifetime of the animal.
At this time, multiple cell divisions already had occurred and eggs were characterized by the presence of the late morula (Stage 1).
Alternately, CFSE dilution of follicular B-cells in response to various TLR agonists was measured and B-cells appear to undergo multiple cell divisions in vitro (data not shown).
Alternatively, we cannot rule out that the conditions used herein may have selected for a sub-population of cells that did not undergo DNA fragmentation and consequently outgrew the apoptotic cell population after multiple cell divisions.
While the results in Figure 4 support our hypothesis that memory PR1-CTL proliferate, labeling to identify phenotypes after proliferation may have biased the results toward cells that undergo multiple cell divisions or that re-express CCR7.
