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Buytaert, E., Dewaele, M. & Agostinis, P. Molecular effectors of multiple cell death pathways initiated by photodynamic therapy.
This would be consistent with the observation that many genotoxic drugs induce multiple cell death pathways35,36,37,38,39.
We further investigated the potential molecular mechanisms of how GX15-070 induces multiple cell death pathways.
Rose Bengal acetate photodynamic therapy (RBAc PDT) induced multiple cell death pathways in HeLa cells through ROS and ER stress.
Taken together, GX15-070 induces multiple cell death pathways such as caspase-dependent, -independent apoptosis, and autophagy.
Simultaneously, the activation of multiple cell death pathways may help to overcome chemotherapy resistance results from single death mode killing.
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First, these pan-caspase inhibitors block an unknown caspase(s) that works upstream of the mitochondria in multiple cell death-inducing systems of U251 cells, and second, these inhibitors work by an unexpected mechanism other than caspase inhibition in U251 cells, as indicated in previous reports.
Particularly, cancer cells can respond to photodynamic injury by initiating a rescue response and/or succumbing to multiple cell deaths.
In other words, we typically do not expect to have multiple cell deaths within a migration radius of a given cell.
Motility, trunk, brain, multiple and cell death categories (16 phenotypes, 43.2%) showed full lethality before settlement and metamorphosis.
This review showed that CMs treatment could induce multiple cancer cell death pathways including apoptosis, autophagy, necrosis, and other kinds of cell death, in which apoptosis is the most dominant type.
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