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In other words, these models are not statistically "identifiable" and multiple causal situations represented by different DAGs can map to a single set of independence assumptions.
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Allelic heterogeneity refers to a situation where multiple causal variants of differing frequency and effect size exist within a gene.
This situation is common in our case of GEMOT modules harboring multiple causal transcripts translating between the same variant and a group of traits.
The methods are illustrated with some application examples covering different causal situations.
The Faithfulness Condition implies that the causal influences of one variable on another along multiple causal routes does not 'cancel'cancel
Using connectors limits the number of causal connections that can be made with any particular event; connectors directly link two events to the exclusion of multiple causal factors.
Yet some cases can be explained by multiple causal paths; thus, raw coverage cannot effectively reflect the explanatory power of one causal path after considering the other causal paths.
The anxiety-like behavior assessed will likely involve multiple causal factors.
How large should our study be to capture multiple causal variants?
Such an approach is not applicable to deal with the discovery of multiple causal variants, since we then have to consider the impact of multiple testing problem.
Moreover, those present are multiallelic, a situation which reflects the complexity observed in the predicted founders' haplotype effects, and suggesting the presence of multiple causal variants (Fig. 6).
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