Sentence examples for multiple caspases followed from inspiring English sources

These compounds trigger the mitochondrial apoptotic pathway that results in the loss of mitochondrial membrane potential through activation of multiple caspases followed by activation of caspase-3, and finally cleavage of PARP.

Figure 1B demonstrates sequential activation of caspase 8 (death receptor initiator caspase) followed by activation of caspase 3 (effector caspase).

A systematic assessment of substrate selectivity uncovered that caspase substrates can be cleaved by multiple caspases.

We also connect intermediate-length ataxin 2 polyQ expansions to the stress-dependent activation of multiple caspases, including caspase 3. Caspase activation is upstream of TDP-43 cleavage and phosphorylation since caspase inhibitors block these pathological modifications.

We transduced cancer cells to overexpress crmA which inhibits initiator caspases including caspase-1 and caspase-8 in the death-receptor pathway [16], or Bcl-2, a well-known inhibitor of multiple caspases in the mitochondrial pathway [17].

Taken together, multiple caspases are activated upon the induction of glioma cell death by CB irradiation.

It inhibited multiple caspases, reduced poly ADP ribose polymerase cleavage, and directly interfered with active caspase-3 on a cell-free assay.

This complex activates initiator caspases, primarily caspase-8, followed by direct or indirect (via the mitochondrial signaling loop) activation of effector caspases, predominantly caspase-3.

In order to test the ability of the purified NEAs to identify multiple caspase substrates, we performed an immuno-precipitation experiment as follows: lysates from healthy or apoptotic HCT-116 cells (±QVD-OPH) were incubated with NEA.

Multiple iterations followed, to improve the product possibilities.

Ten years and multiple diagnoses followed.