Sentence examples for multiple candidate genes from inspiring English sources

Kim DH, Sriharsha L, Xu W, Kamel-Reid S, Liu X, Siminovitch K, et al. Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia.

For example, in reproductive epidemiology, one may collect pregnancy outcomes such as length of gestation and birth weight and predictors such as single nucleotide polymorphisms in multiple candidate genes and environmental exposures.

Previous studies have identified multiple candidate genes and chromosomal regions which influence bone mass and are linked to osteoporosis-related phenotypes [10] [20].

The postsynaptic density (PSD) is a particularly interesting microdomain since multiple candidate genes for psychoses and mood disorders converge on its signaling mechanisms [5], [6], [7], [13].

Quantitative trait linkage studies have already identified multiple candidate genes; however, it is also possible to take an individual candidate gene approach.

Multiple candidate genes for aging have been identified in model systems by extended longevity mutant phenotypes, including the G-protein coupled receptor methuselah (mth) in D. melanogaster.

Markers of osteoclasts (Acp5, MMP9, Ctsk) and the multiple candidate gene Ntrk2 were also expressed at higher levels in the juvenile dura mater.These findings suggest a more differentiated osteoprogenitor population to exist along with a greater presence of osteoclasts in the juvenile dura mater relative to adults.

This resource has been the basis for multiple candidate gene, and genome wide scan analysis, and has identified variants associated with severe retinopathy of prematurity and necrotizing enterocolitis.

Common variants in GCKR, most often the minor T-allele of the common single nucleotide polymorphism (SNP) rs780094, have been reported by multiple candidate gene and GWA studies to be associated with decreased fasting glucose[12] [19] and insulin levels [12], [16], [18], lower insulin resistance[12], [15] [18], [20], and decreased prevalence of type 2 diabetes [12], [15], [16], [18].

Given its position as one of the leading health problems in the world, in the last few years T2D has been the target of 15 genome wide association studies (GWAS) [2] and multiple candidate gene studies (reviewed in [3] and [4]).

In this work we focus on the interleukin receptor (IL4R) gene which has been clearly established as an asthma susceptibility gene in multiple candidate gene association studies [ 3- 5].