Sentence examples for multiple candidate gene from inspiring English sources

Given its position as one of the leading health problems in the world, in the last few years T2D has been the target of 15 genome wide association studies (GWAS) [2] and multiple candidate gene studies (reviewed in [3] and [4]).

Common variants in GCKR, most often the minor T-allele of the common single nucleotide polymorphism (SNP) rs780094, have been reported by multiple candidate gene and GWA studies to be associated with decreased fasting glucose[12] [19] and insulin levels [12], [16], [18], lower insulin resistance[12], [15] [18], [20], and decreased prevalence of type 2 diabetes [12], [15], [16], [18].

Here we present a case study in which we used EnRICH to integrate and filter multiple candidate gene lists in order to identify potential retinal disease genes.

Only one gene has emerged as consistently found in studies of LLI, APOE, though another, FOXO3A, was replicated in multiple candidate gene studies.

In this work we focus on the interleukin receptor (IL4R) gene which has been clearly established as an asthma susceptibility gene in multiple candidate gene association studies [ 3- 5].

Quantitative trait linkage studies have already identified multiple candidate genes; however, it is also possible to take an individual candidate gene approach.

Previous studies have identified multiple candidate genes and chromosomal regions which influence bone mass and are linked to osteoporosis-related phenotypes [10] [20].

The postsynaptic density (PSD) is a particularly interesting microdomain since multiple candidate genes for psychoses and mood disorders converge on its signaling mechanisms [5], [6], [7], [13].

Multiple candidate genes for aging have been identified in model systems by extended longevity mutant phenotypes, including the G-protein coupled receptor methuselah (mth) in D. melanogaster.

The design of the two multiple cloning sites of Pogostick (Fig. 1B), with carefully chosen RE recognition sequences, give the vector its versatility and easiness of use for multiple candidate genes.

We also identified cliques representing the joint effect of multiple candidate genes in all groups, suggesting the existence of biologically plausible combinations of hormone metabolism genes in both breast and endometrial cancer in both races.