Multiple candidate growth factors and inflammatory signals in the lesion environment show strong correlations with GFAP across the acute cuprizone demyelination and recovery time course, yet there is more divergence across the progression of chronic cuprizone demyelination and recovery.
This analysis revealed multiple candidate transcription factors activated in the remnant livers, some known to be involved in the early phase of liver regeneration, and several not previously identified.
Overall, multiple candidate transcription factor binding sites were identified that met these criteria (Fig. 4A).
In our current studies, by dissecting the Col10a1 cis-enhancer, we identified multiple candidate Col10a1-interacting factors, including Cox-2 that has been shown to directly interact with Runx2.
Grothey et al. [3] identified multiple candidate T cell factor (TCF) binding sites in the (mouse) Fscn1 promoter, but found no effect of either TCF or β-catenin over-expression on Fscn1 promoter activity when tested in human MDA-MB-435 cells.
There are a number of established melanoma risk factors, namely light skin pigmentation, intermittent sun exposure and multiple naevi, with some other candidate factors which are currently being investigated, such as exposure to heavy metals, polychlorinated biphenyls, pesticides, and genetic factors modifying response to environmental factors [ 78].
In many gene promoters it is possible to find multiple candidate binding sites for any particular transcription factor.
Among the candidate factors of parasite virulence are the A2 genes, a family of multiple genes that are developmentally expressed in species of the Leishmania donovani group responsible for visceral diseases (VL).
Of those 13 articles developing a multivariable model with multiple candidate predictors for inclusion, the most common approach was to use p-values to decide which factors were included.
