Additionally, the related KMT NSD1 was recently discovered to harbor point mutations in multiple cancers, including HNSCC and AML (Dolnik et al., 2012; Yan et al., 2011).
In this regard, platinum-based drugs (carboplatin and cisplatin) are indicated in the treatment of multiple cancers including cervical cancers [6].
Recently, curcumin has drawn much attention due to its powerful anti-proliferative effect and anticancer activity in multiple cancers including ovarian, pancreatic, breast, melanoma, neck, colon, prostate, and head cancers [16 20].
Epidermal growth factor receptor (EGFR) and c-Met, two well-known receptor kinases, are coexpressed in multiple cancers including hGBM, corroborating that their downstream signaling pathways enhance a malignant phenotype.
The solid tumors of multiple cancers, including that of the breast, are often associated with local inflammation [1].
Indeed, increased SPARC expression has been described in multiple cancers, including colon [24], esophagus [25], pancreas [26], breast [27], lung [28], brain [29], bladder [30], renal [31], and melanoma [18], [32].
Both miR-221 and 222 have shown to be upregulated in multiple cancers including glioblastoma, linked to promoting proliferation and radioresistance by targeting PTEN, p27 and p57 [29]–[31].
Her-2/neu is overexpressed in multiple cancers including lung, prostate and most notably breast cancer.
New genes found frequently mutated in multiple cancers include histone modifiers and chromatin remodelers, most of which are also tumor suppressors.
The mice developed large numbers of multiple liver cancers, including a particularly aggressive type that is rarely seen in the rodents.
Notably, we find that transcriptional or genomic aberrations of BRAFP1 occur frequently in multiple human cancers, including B cell lymphomas.
