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Tumor tissues from multiple cancers have been reported to have elevated copper content [ 22].
Recently, the roles of the immune system in the initiation and progression of multiple cancers have received increasing attention.
Using genechip technology to study multiple types of cancer simultaneously we can identify whether multiple cancers have similar gene expression changes [ 21].
Follow-up in studies of multiple cancers have confirmed these findings [ 20] and have found additional associations for kidney, thyroid, and larynx cancer [ 31], as well as cancers of the upper aerodigestive tract [ 54].
Several clinical trials assessing the efficacy of hTERT vaccines in patients with multiple cancers have been conducted or are underway, and although variations were reported in terms of tumor reductions, specific T cells were commonly induced in the majority of patients, with no adverse toxicities.
Similar(55)
In the past arguments on metastasis cancers or multiple primary cancers have been focused on whether the mutations in the cancer cells of the different sites are similar or not.
Furthermore, multiple gastric cancers have a higher incidence of MSI than solitary gastric cancers, although few studies have focused on the relationship between multiple gastric cancers and MSI (Nakashima et al, 1995; Yamashita et al, 2000; Ogata et al, 2001).
Current understanding is that many agents cause cancer at multiple sites, and many cancers have multiple causes.
Studies in multiple types of cancers have demonstrated that elevated NEK2A promotes cell proliferation, while its suppression with siRNA inhibited this proliferation and induced cell death [ 12, 46, 48– 50].
The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in treating multiple blood cancers has created a need for efficient methods of ex vivo gene delivery to primary human T cells for cell engineering.
The incidence of multiple primary cancers has recently increased.
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