Sentence examples for multiple cancer models from inspiring English sources

It is now well established that EMT correlates with the achievement of stemness traits in multiple cancer models [ 16, 17].

In preclinical studies, volasertib demonstrated broad antitumour activity in multiple cancer models and a promising pharmacokinetic (PK) profile indicative of high and sustained exposure in tumour tissue (Rudolph et al, 2009).

Lastly, the authors used immunohistochemistry to show that EPLIN downregulation is correlated with cancer progression in multiple cancer models including lymph node metastasis in PCa, where EPLIN expression was significantly reduced [ 47].

Reciprocally, knockdown of INPP4B increased both invasion and migration of the steroid receptor negative, basal-like MCF10A breast cancer cells [ 9], suggesting that INPP4B suppression of invasion is common in multiple cancer models.

A defect in caspase activation because of the expression of anti-apoptotic proteins such as XIAP is believed to be an important mechanism of acquired therapeutic resistance in multiple cancer models (Sasaki et al, 2000; Li et al, 2001; Mansouri et al, 2003; Amantana et al, 2004; Yang et al, 2005; Schimmer et al, 2006; Aird et al, 2008).

Inhibitors of Hsp90 (Hsp90-I) effect numerous proteins and pathways that are critical to the etiology of prostate cancer [ 2- 4] and have demonstrated significant anti-proliferative effects in multiple cancer models, many of which are being evaluated in clinical trials [ 5].

These and our data indicate that niclosamide is able to induce autophagy in multiple cancer cell models.

We have also reported that CR strongly suppresses tumor development and growth in multiple mammary cancer models.

One of these genes, β1-integrin, has been implicated in therapeutic resistance in multiple solid cancer models [ 20, 21].

Furthermore, β1-integrin, which coordinates much broader functional processes such as inflammation, proliferation, adhesion, and invasion, has recently been implicated in therapeutic resistance in multiple solid cancer models [ 20, 21].

In combination with radiation, synergistic cell death effects were observed both in vitro and in multiple preclinical lung cancer models.