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The coupling of electrochemical devices with nanomaterials offers a unique capability for accurate measurements of multiple cancer markers from a variety of cancer patient samples.
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Another advantage includes that cell screening based on multiple cancer cell markers could provide additional pathological information on cancer progress.
We investigated the expression of multiple cancer stem cell markers in human breast cancer samples and cell lines in vitro and in vivo, comparing across and within samples and relating expression with growth and therapeutic response to doxorubicin, docetaxol and radiotherapy.
Furthermore, based on Oncomine [ 10] data, we found that the gene expression analysis of the OVOL-TFs significantly correlates with the expression of MET markers in multiple cancer types.
The results obtained are found to be promising and can possibly have important impact in the area of unsupervised cancer classification as well as gene marker identification for multiple cancer subtypes.
By working on multiple cancer types simultaneously, we can derive potential markers either specific to individual cancer types or general to all or groups of cancers, as well as to identify abnormally activated or deactivated pathways.
Our results indicate potentially important roles of REGγ in multiple cancer types and implicate REGγ as a putative cancer marker.
Our results indicate potentially important pathogenic roles of REGγ in multiple cancer types and implicate REGγ as a putative cancer marker.
A computational protocol for predicting gene markers in cancer tissues and protein markers in sera was developed for simultaneous analyses of multiple cancer types.
The confirmation of several of these genes in a p53 related breast cancer signature suggests that a core set of expression markers could be developed to assess p53 activity in multiple cancer types.
In addition to individual gene markers, we have focused on gene combinations that can be used to distinguish multiple cancer types from their corresponding control tissues.
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